Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers
نویسندگان
چکیده
منابع مشابه
Potent RNAi by short RNA triggers.
RNA interference (RNAi) is a gene-silencing mechanism by which a ribonucleoprotein complex, the RNA-induced silencing complex (RISC) and a double-stranded (ds) short-interfering RNA (siRNA), targets a complementary mRNA for site-specific cleavage and subsequent degradation. While longer dsRNA are endogenously processed into 21- to 24-nucleotide (nt) siRNAs or miRNAs to induce gene silencing, RN...
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ژورنال
عنوان ژورنال: Nucleic Acid Therapeutics
سال: 2017
ISSN: 2159-3337,2159-3345
DOI: 10.1089/nat.2017.0686